DILAUDID-HP Injection (hydromorphone hydrochloride) 10mg/mL


DILAUDID-HP Injection (hydromorphone hydrochloride) 10mg/mL


(hydromorphone hydrochloride) and

(hydromorphone hydrochloride), for intravenous, intramuscular, or subcutaneous use

Hydromorphone HCl 10mg/mL; soln for IV, IM or SC inj; preservative-free; contains sulfites.



Brand Names: Dilaudid, Dilaudid-HP

Generic Name: hydromorphone (injection) (Pronunciation: hy dro MOR fone)

  • What is hydromorphone injection (Dilaudid, Dilaudid-HP)?
  • What are the possible side effects of hydromorphone injection (Dilaudid, Dilaudid-HP)?
  • What is the most important information I should know about hydromorphone injection (Dilaudid, Dilaudid-HP)?
  • What should I discuss with my healthcare provider before receiving hydromorphone injection (Dilaudid, Dilaudid-HP)?
  • How is hydromorphone injection given (Dilaudid, Dilaudid-HP)?
  • What happens if I miss a dose (Dilaudid, Dilaudid-HP)?
  • What happens if I overdose (Dilaudid, Dilaudid-HP)?
  • What should I avoid while receiving hydromorphone injection (Dilaudid, Dilaudid-HP)?
  • What other drugs will affect hydromorphone injection (Dilaudid, Dilaudid-HP)?
  • Where can I get more information?

What is hydromorphone injection (Dilaudid, Dilaudid-HP)?

Hydromorphone is an opioid pain medication. An opioid is sometimes called a narcotic.

Hydromorphone injection is used to treat moderate to severe pain.

Hydromorphone injection may also be used for purposes not listed in this medication guide.

What are the possible side effects of hydromorphone injection (Dilaudid, Dilaudid-HP)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • weak or shallow breathing, feeling like you might pass out.;
  • pounding heartbeats or fluttering in your chest;
  • wheezing, chest tightness, trouble breathing;
  • seizure (convulsions); or
  • confusion, severe weakness or drowsiness.

Less serious side effects may include:

  • blurred vision, double vision;
  • flushing (warmth, redness, or tingly feeling);
  • nausea, vomiting, constipation, diarrhea, stomach pain;
  • dizziness, drowsiness;
  • pain where the injection was given;
  • dry mouth;
  • sweating, itching; or;
  • sleep problems (insomnia), or strange dreams.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydromorphone injection (Dilaudid, Dilaudid-HP)?

You should not use this medication if you have ever had an allergic reaction to a narcotic medicine, if you have paralytic ileus (a bowel obstruction), or if you are having an asthma attack.

Hydromorphone may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.

Do not drink alcohol while you are receiving hydromorphone. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine.

Avoid driving or operating machinery until you know how hydromorphone will affect you.

Do not stop using hydromorphone suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using hydromorphone.



Management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in opioid-tolerant patients who require higher doses.

Limitations Of use:

Reserve for use in patients for whom alternative treatment options have not been tolerated or not provided adequate analgesia.


Use in opioid-tolerant patients only. Individualize; base starting dose on prior Dilaudid inj or prior dose of alternate opioid: see full labeling.


Not established.


Significant respiratory depression. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment. Known or suspected GI obstruction, including paralytic ileus. Dilaudid-HP: opioid non-tolerant.


Life-threatening respiratory depression; monitor within first 24–72hrs of initiating therapy and following dose increases. COPD, cor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression; monitor and consider non-opioid analgesics. Abuse potential (monitor). Adrenal insufficiency. Head injury. Increased intracranial pressure, brain tumors; monitor. Seizure disorders. CNS depression. Impaired consciousness, coma, shock; avoid. Biliary tract disease. Acute pancreatitis. Drug abusers. Renal or hepatic impairment. Reevaluate periodically. Avoid abrupt cessation. Elderly. Cachectic. Debilitated. Pregnancy; potential neonatal opioid withdrawal syndrome during prolonged use. Labor & delivery: not recommended. Nursing mothers: monitor infants.


Increased risk of hypotension, respiratory depression, sedation with benzodiazepines or other CNS depressants (eg, non-benzodiazepine sedatives/hypnotics, anxiolytics, general anesthetics, phenothiazines, tranquilizers, muscle relaxants, antipsychotics, alcohol, other opioids); reserve concomitant use in those for whom alternative options are inadequate; limit dosages/durations to minimum required; monitor. During or within 14 days of MAOIs: not recommended. Risk of serotonin syndrome with serotonergic drugs (eg, SSRIs, SNRIs, TCAs, triptans, 5-HT3 antagonists, mirtazapine, trazodone, tramadol, MAOIs, linezolid, IV methylene blue); monitor and discontinue if suspected. Avoid concomitant mixed agonist/antagonist opioids (eg, butorphanol, nalbuphine, pentazocine) or partial agonist (eg, buprenorphine); may reduce effects and precipitate withdrawal symptoms. May antagonize diuretics; monitor. Paralytic ileus may occur with anticholinergics.

See Also:


Pharmacological Class:

Opioid agonist.

Adverse Reactions:

Lightheadedness, dizziness, sedation, nausea, vomiting, sweating, flushing, dysphoria, euphoria, dry mouth, pruritus; respiratory depression, severe hypotension, syncope.

How Supplied:

Prefilled syringes—24


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